Resident
Gage, Brittany, BSc, PharmD
Residency Program
LMPS
Project Title
Comparison of Tetrasodium EDTA 4% to Sodium Citrate 4% as Line-locking Solutions at Two Tertiary Hemodialysis Centres
Investigators
Karen Shalansky, B.Sc.(Pharm.), PharmD, ACPR, FCSHP and Wynnie Wing Sze Lau, B.Sc.(Pharm.), PharmD, ACPR, Claire Harris, MD, FRCPC, Mercedeh Kiaii MD, FRCPC
Abstract
Sodium citrate 4% is instilled into hemodialysis central venous catheters between dialysis runs to maintain line patency. If a line occlusion occurs due to thrombus or fibrin sheath formation, alteplase is instilled to restore flow. However, alteplase is considerably more expensive than sodium citrate 4%. Tetrasodium EDTA 4% is a new line-locking solution that has been shown to reduce alteplase usage in vivo, and biofilm formation in vitro. The purpose of our study is to compare EDTA 4% to sodium citrate 4% in its ability to maintain HD pump speeds and reduce alteplase usage.
