Resident
George, Kelly, BSc, BSc (Pharm)
Residency Program
Island Health
Project Title
Ceftriaxone as Home Intravenous Therapy for Deep-Seated Methicillin-Sensitive Staphylococcus aureus Infections
Investigators
Powell, Lyle (BSc(Pharm), ACPR), Stewart, Michelle (BSc(Pharm), ACPR); McGinnis, Mark (PharmD, ACPR); Piszczek, Jolanta (BSc(Pharm), Pharm D, MSc)
Abstract
Deep-seated methicillin-sensitive Staphylococcus aureus (MSSA) infections require many weeks of intravenous antibiotic therapy. Typical therapy for these infections in Canada include cloxacillin or cefazolin. Use of these agents may be a barrier to patient admission into an outpatient antimicrobial therapy program as they require multiple daily doses. Once daily agents such as ceftriaxone are an attractive alternative; however, their role in treating MSSA infections has not been well defined. The purpose of this study is to compare the rates of clinical cure and adverse drug events between standard of care agents (cloxacillin and cefazolin) and ceftriaxone.
